The NOX-ROS connection: targeting Nox1 control of N-cadherin shedding in vascular smooth muscle cells
نویسندگان
چکیده
منابع مشابه
Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.
AIMS In atherosclerosis and restenosis, vascular smooth muscle cells (SMCs) migrate into the subendothelial space and proliferate, contributing to neointimal formation. The goal of this study was to define the signalling pathway by which Nox1 NAPDH oxidase mediates SMC migration. METHODS AND RESULTS SMCs were cultured from thoracic aorta from Nox1(-/y) (Nox1 knockout, KO) and wild-type (WT) m...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2012
ISSN: 0008-6363
DOI: 10.1093/cvr/cvs020